院长、教授
电子邮箱：wqchen@nju.edu.cn
2026 – 至今 南京大学 生物医学工程学院，院长、教授
2024 – 2026 纽约大学 生物医学工程系、机械与航空工程系，教授、研究生教育主任
2023 – 2025 纽约大学 机械与航空工程系，科研主任
2021 – 2023 纽约大学 机械与航空工程系，本科生教育主任
2020 – 2024 纽约大学 生物医学工程系、机械与航空工程系，副教授
2019 – 2026 纽约大学 医学院癌症研究所，双聘研究员
2014 – 2020 纽约大学 机械与航空工程系，助理教授
2010 – 2014 密歇根大学 机械工程系，博士
2008 – 2009 普度大学 电子与计算机工程系，硕士
2005 – 2008 上海交通大学 微纳科学技术研究院，硕士
2001 – 2005 南京大学 物理学院，学士
研究融合器官芯片和类器官与临床肿瘤学、以及生物传感器芯片技术，开创“芯片上肿瘤微环境”与“芯片上临床试验”研究新方向，在癌症免疫治疗、自身免疫性疾病，免疫系统模拟和疫苗研发等生物医学交叉领域取得多项突破性成果，为促进病理机制研究、临床诊断、创新药物开发和精准医疗提供了新的工具与方法策略。相关成果发表于Nature Biomedical Engineering，Nature Immunology，Nature Materials，Nature Physics，Nature Methods, Nature Protocols，Nature Communications，Science Advances，Cancer Cell，eLife，Advanced Materials等国际权威期刊。曾主持国际重大科研项目20 余项，总经费逾6300 万元，参与创建了全球首个新型动物替代方法数据研究中心（获美国国立卫生研究院1.7 亿元资助），并担任其科学顾问委员会主席，参与建立新方法国际标准。
奖励荣誉
2024 美国国立卫生研究院补充动物实验研究创新挑战奖
2023 美国心脏学会会士(Fellow of the American Heart Association, FAHA)
2021 英国皇家化学会《化学通讯》杂志新锐科学家奖
2021 美国生物医学工程学会细胞与分子生物工程新星奖
2021 日本国家医学研究基金健康长寿创新奖
2020 纽约科学院优秀青年学者奖
2019 美国国立卫生研究院国家综合医学科学研究所杰出青年学者基金
2019 Chroma生物医学工程杰出青年科学家奖
2019 美国生物医学工程学会细胞与分子生物工程青年创新奖
2019 亚洲细胞治疗组织年会（日本札幌）最佳论文奖
2018 美国国立卫生研究院国家生物医学影像与生物工程研究所开拓者奖
2018 英国皇家化学会《芯片实验室》新锐科学家奖
2017 纽约大学Goddard杰出青年教授研究奖
2017 纽约大学Whitehead生物医学青年学者基金奖
2016 美国心脏协会科学家发展奖
2014 密歇根大学ProQuest优秀博士论文奖
2013 密歇根大学工学院Richard & Eleanor Towner杰出博士研究奖
2013 第二届美国机械工程师学会全球医学纳米工程大会优秀论文奖
2013 百特医疗集团杰出青年科学家奖
2013 美国心脏协会优秀博士生奖学金
2011 化学生物微系统学会优秀青年研究奖
代表著作
1. Raymond H.W. Lam and Weiqiang Chen, Biomedical Devices: Materials, Design, and Manufacturing, Springer Nature, 2019. ISBN 978-3-030-24236-7（教科书）
2. Yi Liu, Baoce Sun, Shuhuan Hu, Ngoc Luu, Jifeng Ren, Lelin Liu, Jingqian Zhang, Yun Qu, Ruolin Zhang, Jialei Song, Mo Yang, Ao Zhou, Hanbai Wu, Dong Sun, Jinlian Hu, Denvid Lau, Weiqiang Chen, Raymond H. W. Lam, Three-dimensional cell morphology is mediated by curvature sensing and interfacial stress, Nature Physics, 2026, in press.
3. Huishu Wang, Lunan Liu, Weiqiang Chen, An immunocompetent bone marrow-on-a-chip model for for studying human hematological malignancies and preclinical therapeutic screening, Nature Protocols, 2026, in press.
4. Chao Ma, Huishu Wang, Lunan Liu, Ruiqi Chen, Nandana Mukherjee, Jie Tong, Shadab Kazmi, Xiangyi Fang, Matthew T. Witkowski, Iannis Aifantis, Saba Ghassemi, Weiqiang Chen, Bioengineered immunocompetent preclinical trial-on-chip tool enables screening of CAR T cell therapy for leukaemia, Nature Biomedical Engineering, 2025, 9, 2098–2114.
5. Ngoc Luu, Apratim Bajpai, Rui Li, Seojin Park, Mahad Noor, Xiao Ma, and Weiqiang Chen, Aging-associated Decline in Vascular Smooth Muscle Cell Mechanosensation is Mediated by Piezo1 Channel, Aging Cell, 2023, 23, e14036.
6. Benteng Ma, Xinya Liu, Zhuoyu Zhang, Chao Ma, Rashik Chand, Saee Patwardhan, Chuanyu Wang, Soracha D. Thamphiwatana, Pengyu Chen, and Weiqiang Chen, A Digital Nanoplasmonic Microarray Immunosensor for Multiplexed Cytokine Monitoring during CAR T-Cell Therapy from a Leukemia Tumor Microenvironment Model, Biosensors and Bioelectronics, 2023, 115247.
7. Lunan Liu, Chao Ma, Zhuoyu Zhang, Matthew T. Witkowski, Iannis Aifanti, Saba Ghassemi, Weiqiang Chen, Computational model of CAR T-cell immunotherapy dissects and predicts leukemia patient responses at remission, resistance, and relapse, Journal for ImmunoTherapy of Cancer, 2022, 10, e005360.
8. Matthew T. Witkowski, Soobeom Lee, Eric Wang, Anna Lee, Alexis Talbot, Chao Ma, Nikolaos Tsopoulidis, Justin Brumbaugh, Yaqi Zhao, Kathryn G. Roberts, Simon J. Hogg, Sofia Nomikou, Yohana Ghebrechristos, Palaniraja Thandapani, Charles Mullighan, Konrad Hochedlinger, Weiqiang Chen, Omar Abdel-Wahab, Justin Eyquem, Iannis Aifantis, NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia, Nature Immunology, 2022, 23, 1424-1432.
9. Weiyi Qian, Tarik Hadi, Michele Silvestro, Xiao Ma, Cristobal F. Rivera, Apratim Bajpai, Rui Li, Zijing Zhang, Hengdong Qu, Rayan Sleiman Tellaoui, Annanina Corsica, Ariadne L. Zias, Karan Garg, Thomas Maldonado, Bhama Ramkhelawon, Weiqiang Chen, Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1, Nature Communications, 2022, 13, 512.
10. Chao Ma, Yansong Peng, Hongtong Li, Weiqian Chen, Organ-on-a-Chip: A new paradigm for drug development, Trends in Pharmacological Sciences, 2021, 42, 2, 119-133.
11. Chao Ma, Matthew T. Witkowski, Jacob Harris, Igor Dolgalev, Sheetal Sreeram, Weiyi Qian, Jie Tong, Xin Chen, Iannis Aifantis, Weiqian Chen, Leukemia-on-a-Chip: Dissecting the chemo-resistance mechanisms in B-cell acute lymphoblastic leukemia bone marrow niche, Science Advances, 2020, 6, eaba5536.
12. Xin Cui, Chao Ma, Varshini Vasudevaraja, Jonathan Serrano, Jie Tong, Yansong Peng, Michael Delorenzo, Guomiao Shen, Joshua Frenster, Renee-Tyler Tan Morales, Weiyi Qian, Aristotelis Tsirigos, Andrew S. Chi, Rajan Jain, Sylvia C. Kurz, Erik P. Sulman, Dimitris Placantonakis, Matija Snuderl, Weiqiang Chen, Dissecting the heterogeneity of immunosuppressive tumor microenvironments in a Glioblastoma-on-a-Chip for optimized anti-PD-1 immunotherapy, eLife, 2020, 9, e52253.
13. Matthew T Witkowski, Igor Dolgalev, Nikki A Evensen, Chao Ma, Tiffany Chambers, Kathryn G Roberts, Sheetal Sreeram, Yuling Dai, Anastasia N Tikhonova, Audrey Lasry, Chunxu Qu, Deqing Pei, Cheng Cheng, Gabriel A Robbins, Joanna Pierro, Shanmugapriya Selvaraj, Valeria Mezzano, Marla Daves, Philip J Lupo, Michael E Scheurer, Cynthia A Loomis, Charles G Mullighan, Weiqiang Chen, Karen R Rabin, Aristotelis Tsirigos, William L Carroll, Iannis Aifantis, Extensive remodeling of the immune microenvironment in B cell acute lymphoblastic leukemia. Cancer Cell, 2020, 37, 6, 867-882.e12.
14. Qianbin Wang, Weiyi Qian, Xiaoyu Xu, Apratim Bajpai, Kevin Guan, Zijing Zhang, Roy Chen, Vittoria Flamini, and Weiqiang Chen, Energy-mediated machinery drives cellular mechanical allostasis, Advanced Materials, 2019, 1900453.
15. Shinuo Weng, Yue Shao, Weiqiang Chen, and Jianping Fu, Mechanosensitive subcellular rheostasis drives emergent single-cell mechanical homeostasis, Nature Materials, 2016, 15, 961-967.
16. Yubing Sun, Koh Meng Aw Yong, Luis G. Villa-Diaz, Xiaoli Zhang, Weiqiang Chen, Renee Philson, Shinuo Weng, Haoxing Xu, Paul H. Krebsbach, Jianping Fu , Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells, Nature Materials, 2014, 13, 599-604.
17. Ankur Singh, Shalu Suri, Ted Lee, Jamie M Chilton, Marissa T Cooke, Weiqiang Chen, Jianping Fu, Steven L Stice, Hang Lu, Todd C McDevitt, Andrés J García, Adhesive signature-based, label-free isolation of reprogrammed human induced pluripotent stem cells, Nature Methods, 2013, 10, 438-444.
