柯东旭

副教授

电子邮箱:dongxu.ke@nju.edu.cn

教育履历

本科毕业于合肥工业大学(2007-2011),硕博毕业于美国华盛顿州立大学(2011-2017),师从“总统提名 20 位最有前途科学家”Susmita Bose 教授。曾在美国维克森林再生医学研究所跟随再生医学之父Anthony Atala教授从事生物3D打印与再生医学研究。加入南京大学前曾任苏州诺普再生医学有限公司首席技术官,负责3D打印可吸收三类医疗器械的开发与转化,被授予创新领军人才称号。

研究兴趣
目前主要研究方向为新型生物材料的开发、增材制造技术的改进、以及两者相结合在组织工程领域的应用。本课题组致力于医工结合,希望通过新技术的开发解决临床痛点,为广大患者带来福音。
主要学术成绩

先后承担了江苏省自然科学基金、江苏省重点研发计划、国家重点研发计划等重要研究任务,并取得突出的研究成果,发表高影响力SCI文章与专著共23篇,引用超2000次,申请美国专利1项,中国专利17项。

文章:

1.D. Ke, W. Dernell, A. Bandyopadhyay, S. Bose*, Doped Tricalcium Phosphate Scaffolds by Thermal Decomposition of Naphthalene: Mechanical Properties and In vivo Osteogenesis in a Rabbit Femur Model, J. Biomed. Mater. Res. B Appl. Biomater. 103 (2015) 1549–1559. [Impact Factor: 3.386] 

2.D. Ke, S.F. Robertson, W.S. Dernell, A. Bandyopadhyay, S. Bose*, Effects of MgO and SiO2 on PlasmaSprayed Hydroxyapatite Coating: An in Vivo Study in Rat Distal Femoral Defects, ACS Appl. Mater. Interfaces. 9 (2017) 25731–25737. [Impact Factor: 9.229] 

3.D. Ke, S. Bose*, Doped tricalcium phosphate bone tissue engineering scaffolds using sucrose as template and microwave sintering: enhancement of mechanical and biological properties, Mater. Sci. Eng. C. 78 (2017) 398–404. [Impact Factor: 7.060] 

4.Y. Chen, Q. Fu, D. Li, J. Xie, D. Ke, Q. Song, Y. Tang*, H. Wang*, A smartphone colorimetric reader integrated with an ambient light sensor and a 3D printed attachment for on-site detection of zearalenone, Anal. Bioanal. Chem. 409 (2017) 6567–6574. [Impact Factor: 4.142] 

5.D. Ke, S. Bose*, Effects of pore distribution and chemistry on physical, mechanical, and biological properties of tricalcium phosphate scaffolds by binder-jet 3D printing, Addit. Manuf. 22 (2018) 111–117. [Impact Factor: 10.998] 

6.S. Bose*, D. Ke, H. Sahasrabudhe, A. Bandyopadhyay*, Additive manufacturing of biomaterials, Prog. Mater. Sci. 93 (2018) 45–111. [Impact Factor: 39.580] 

7.D. Ke, S. Murphy*, Current Challenges of Bioprinted Tissues towards Clinical Translation, Tissue Eng. Part B Rev. (2018). [Impact Factor: 6.389] 

8.D. Ke, S. Tarafder, S. Vahabzadeh, S. Bose*, Effects of MgO, ZnO, SrO, and SiO2 in tricalcium phosphate scaffolds on in vitro gene expression and in vivo osteogenesis, Materials Science and Engineering: C. 96 (2019) 10–19. [Impact Factor: 7.060] 

9.D. Ke, A.A. Vu, A. Bandyopadhyay, S. Bose*, Compositionally graded doped hydroxyapatite coating on titanium using laser and plasma spray deposition for bone implants, Acta Biomaterialia. 84 (2019) 414–423. [Impact Factor: 8.947] 

10.D. Ke, D. Banerjee, S. Bose*, In Vitro Characterizations of Si4+ and Zn2+ Doped Plasma Sprayed Hydroxyapatite Coatings Using Osteoblast and Osteoclast Coculture, ACS Biomater. Sci. Eng. 5 (2019) 1302– 1310. [Impact Factor: 4.511] 

11.S. Bose*, S. Vahabzadeh, D. Banerjee, D. Ke, Enhanced osteogenic protein expression on human osteoblast-osteoclast co-culture system using doped hydroxyapatite plasma coatings for orthopedic and dental applications, Materials Today Communications. 21(2019),100534. [Impact Factor: 3.383] 

A.Vu, S. Robertson, D. Ke, A. Bandyopadhyay, S. Bose*, Mechanical and biological properties of ZnO, SiO2, and Ag2O doped plasma sprayed hydroxyapatite coating for orthopaedic and dental applications, Acta Biomaterialia. 92 (2019) 325–335. [Impact Factor: 8.947] 

12.D Ke, H Yi, S Est-Witte, S George, C Kengla, SJ Lee, A Atala, SV Murphy*, Bioprinted trachea constructs with patient-matched design, mechanical and biological properties, Biofabrication 12 (1), 015022. [Impact Factor: 9.954] 

13.L. Xu, M. Varkey, A. Jorgensen, J. Ju, Q. Jin, J.H. Park, Y. Fu, G. Zhang, D. Ke, W. Zhao, R. Hou*, A. Atala*, Bioprinting small diameter blood vessel constructs with an endothelial and smooth muscle cell bilayer in a single step, Biofabrication. 12 (2020) 045012. [Impact Factor: 9.954] 

14.S. Bose*, D. Ke, A.A. Vu, A. Bandyopadhyay, S.B. Goodman, Thermal Oxide Layer Enhances Crystallinity and Mechanical Properties for Plasma-Sprayed Hydroxyapatite Biomedical Coatings, ACS Appl. Mater. Interfaces. 12 (2020) 33465–33472. [Impact Factor: 9.229] 

15.D Ke, AM Jorgensen, SJ Lee, JJ Yoo, SV Murphy*. Adenosine-treated bioprinted muscle constructs prolong cell survival and improve tissue formation. Bio-des. Manuf. 4 (2021) 441–451. [Impact Factor: 6.302] 

16.D. Ke*, C. Niu, X. Yang*, Evolution of 3D bioprinting-from the perspectives of bioprinting companies, Bioprinting. 25 (2022) e00193. 生物打印领域权威期刊 

17.D. Ke*, J. Yu, P. Liu, C. Niu, X. Yang*, Biomimetic 3D printed PCL/TCP/GelMA scaffolds with improved osteogenesis and angiogenesis for non-load bearing applications, Materialia. 21 (2022) 101339. [Impact Factor: 3.4] 

18.C. Niu, L. Wang, D. Ji, M. Ren, D. Ke, Q. Fu, K. Zhang* X. Yang*, Fabrication of SA/Gel/C scaffold with 3D bioprinting to generate micro-nano porosity structure for skin wound healing: a detailed animal in vivo study, Cell Regeneration, (2022) 11:10. 

19.D. Ke, C. Kengla, S. Lee, J. Yoo, X. Zhu* and S Murphy*, Release Kinetics and In Vitro Characterizations of Sodium Per-carbonate and Calcium Peroxide for Overcoming to Oxygenate Shortage in Bioprinted Tisssue Models Bioprinting Applications, Int. J. Mol. Sci. 2022, 23(12). [Impact Factor: 5.924] 

20.Y. Zhang, D. Li, Y. Liu, L. Peng, D. Lu, P. Wang, D. Ke, H. Yang, X. Zhu, C. Ruan, 3D-bioprinted anisotropic bicellular living hydrogels boost osteochondral regeneration via reconstruction of cartilage–bone interface, 5 (2024) 100542. [Impact Factor: 32.1]