乔治亚理工化学与生化专业博士

美国艾默里大学生物医学工程学系研究助理教授

2013年至今为南京大学生物医学工程系教授，江苏省特聘教授称号。

1. 数字化荧光影像手术导航技术在临床医学中的应用，包括：设备核心器件的设计和优化，新型荧光显影剂的设计、合成与应用。 2. 新药的设计、合成与应用，包括：新机理药物的设计与表征，机理探索，成药性评价，新药申报等。

先后承担国家科技部重点研发计划、国家重大科学仪器研发项目、江苏省重点研发计划等重要研究任务，并取得突出的研究成果，发表高影响力SCI文章100余篇，引用超2000次。

近五年发表论文

[1] Zhuang DW, Li HB, Wang YQ, et al. Nanoparticle-elicited eustress intensifies cucumber plant adaptation to water deficit. Environmental Science & Technology, 2025, 59(7): 3613-3623

[2] Yuan SN, Hu DH, Gao DY, et al. Recent advances of engineering cell membranes for nanomedicine delivery across the blood-brain barrier. Journal of Nanobiotechnology, 2025, 23(1): 

[3] Wang ZY, Dai B, Li YL, et al. Signal-to-noise ratio imaging and real-time sharpening of tumor boundaries for image-guided cancer surgery. Analytical Chemistry, 2025, 97(15): 8516-8527

[4] Li YL, Guissi NE, Dong JM, et al. Fluorescence discrimination of cancer from inflammation by selective targeting folate receptor α. Chemical & Biomedical Imaging, 2025, 

[5] Gong JY, Li YL, Di H, et al. Combined pet and near-infrared fluorescence probe based on lapatinib targeting her2 for in vivo tumor imaging. Bioorganic Chemistry, 2025, 161(

[6] Fang TL, Li L, Wang SN, et al. Therapeutic adoptive cell transfer (act) vaccine patch: Bioengineered tumor cells prime macrophage immunoregulation to prevent postsurgical tumor recurrence and metastasis. Advanced Functional Materials, 2025, 35(49): 

[7] Fang TL, Li L, Muhseen ZT, et al. Strategic timing of gene silencing: Cellular kinetics-based administration of sirna for optimized photothermal cancer treatment. Advanced Science, 2025, 12(44): 

[8] Cheng X, Dong JM, Jain P, et al. Ultrasound activated hybrid-biomimetic nanocarriers that combine tumor-confined crispr/cas9 metabolic reprogramming and cuproptosis with anticancer macrophage polarization. Small, 2025, 

[9] Zhu LJ, Li JR, Pan J, et al. Precise identification of glioblastoma micro-infiltration at cellular resolution by raman spectroscopy. Advanced Science, 2024, 11(36): 

[10] Zhou QQ, Guo JX, Wang ZY, et al. Rapid visualization of pd-l1 expression level in glioblastoma immune microenvironment via machine learning cascade-based raman histopathology. Journal of Advanced Research, 2024, 65(257-271

[11] Zhang W, Jiang JD, Liu T, et al. A rapid and ultrasensitive cardiac troponin i aptasensor based on an ion-sensitive field-effect transistor with extended gate. Talanta, 2024, 277(

[12] Wang JQ, Ruan XY, Guan HM, et al. Drug efficacy comparison of ph-sensitive and non-ph-sensitive taxol delivery nanoparticles in cancer therapy. Macromolecular Bioscience, 2024, 24(7): 

[13] Liu L, Pan J, Qi C, et al. Application research of pulmonary nodule localization techniques in video-assisted thoracic surgery. Chinese Journal of Academic Radiology, 2024, 7(1): 40-49

[14] Liu K, You Q, Jawed R, et al. Purine-doped g-c3n4-modified fabrics for personal protective masks with rapid and sustained antibacterial activity. Acs Applied Bio Materials, 2024, 7(5): 2911-2923

[15] Li YL, Li CM, Li JM, et al. Enhanced tumor targeting and penetration of fluorophores via irgd peptide conjugation: A strategy for the precision targeting of lung cancer. Translational Lung Cancer Research, 2024, 13(8): 

[16] Li L, Guissi NE, Peng YS, et al. Butterfly oscillation of an icg dimer enables ultra-high photothermal conversion efficiency. Cell Reports Physical Science, 2024, 5(1): 

[17] Lane LA, Zhang JL, Wang YQ. Amp coated sers nanotags with hydrophobic locking: Maximizing brightness, stability, and cellular targetability. Journal of Colloid and Interface Science, 2024, 663(295-308

[18] Dai B, Zhou Y, Hajiarbabi M, et al. Accurate categorization and rapid pathological diagnosis correction with micro-raman technique in human lung adenocarcinoma infiltration level. Translational Lung Cancer Research, 2024, 13(4): 

[19] Dai B, Yu A, Zhao GF, et al. Advantages and rational application of indocyanine green fluorescence in pulmonary nodule surgery: A narrative review. Journal of Thoracic Disease, 2024, 16(10): 7192-7203

[20] Xiong YJ, Wang YQ, Wang YS, et al. Improving drug discovery with a hybrid deep generative model using reinforcement learning trained on a bayesian docking approximation. Journal of Computer-Aided Molecular Design, 2023, 37(11): 507-517

[21] Xie DY, Li YL, Shi JH, et al. A novel near-infrared egfr targeting probe for metastatic lymph node imaging in preclinical mouse models. Journal of Nanobiotechnology, 2023, 21(1): 

[22] Wang ZY, Li YL, Yu JH, et al. Combined indocyanine green and medical glue enables stable and precise position in animal studies: Promising for fluorescence-guided pulmonary ground glass nodule resection. Translational Lung Cancer Research, 2023, 12(9): 1923-1934

[23] Peng YS, Li YL, Li L, et al. Coating influence on inner shell water exchange: An underinvestigated major contributor to spions relaxation properties. Nanomedicine-Nanotechnology Biology and Medicine, 2023, 54(

[24] Li L, Ma XX, Peng YS, et al. Bright asymmetric shielding strategy-based nir-ii probes for angiography and localized photothermal therapy. Acs Applied Bio Materials, 2023, 6(4): 1639-1649

[25] Zhao YS, Song QY, Lin YB, et al. Improving the photostability of fluorescent dyes by polymer nano-insulating layer. Journal of Applied Polymer Science, 2022, 139(6): 

[26] Wang YS, Xiong YJ, Garcia EAL, et al. Drug chemical space as a guide for new herbicide development: A cheminformatic analysis. Journal of Agricultural and Food Chemistry, 2022, 

[27] Song QY, Yue JT, Zhao YS, et al. Highly fluorescent functionalized nano-poly(para-phenylene ethynylene) by polymer modification. Polymer, 2022, 245(

[28] Li YL, You Q, Wang ZY, et al. A study on setting standards for near-infrared fluorescence-image guided surgery (nirfgs) time lapse monitoring based on preoperative liver function assessment. Annals of Translational Medicine, 2022, 10(2): 

[29] He XC, Meng LQ, Liu YL, et al. Carbon nitride with rationally designed π-conjugated structure for bright blue-violet light-emitting diodes. Small, 2022, 18(31): 

[30] Guo JX, Liu YQ, Zhang LJ, et al. An ascorbic acid-responsive chemo-chromic sers sensing chip for synergistic dual-modal on-site analysis of alkaline phosphatase. Sensors and Actuators B-Chemical, 2022, 371(

[31] Dai B, Wang ZY, Lu Q, et al. Unexpected detection of a submillimeter early hepatocellular carcinoma focus by intraoperative near-infrared fluorescence imaging-a case report. Annals of Translational Medicine, 2022, 10(10): 

[32] Dai B, Guissi NEI, Sulyok LF, et al. Advantages of using indocyanine green in liver transplantation: A narrative review. Annals of Translational Medicine, 2022, 10(2):