叶德庄博士，南京大学准聘副教授，海外高层次人才。本科毕业于西安交通大学能源动力工程与自动化专业，硕士毕业于美国康涅狄格大学机械工程专业，博士毕业于圣路易斯华盛顿大学机械工程专业，博士后继续在圣路易斯华盛顿大学医学院进行训练，合作导师陈红。

成果：

以第一作者身份（含共同第一作者）在PNAS、eBioMedicine、Journal of Controlled Release、Small等Top期刊发表原创研究论文10篇，并以合作作者身份在Nature Metabolism等发表文章14篇，受邀撰写书籍章节和为Advanced Drug Delivery Review撰写综述论文，论文总他引次数达1000余次。荣获聚焦超声协会颁发的2022年度Bracco’s Women in Focused Ultrasound奖、Young Investigator award，美国声学学会学生科研论文竞赛第一名、聚焦超声协会博士后奖学金、脑免疫学和胶质细胞研讨会NatureNeuro Award以及美国基因与细胞治疗学会年会最佳墙报展示奖（10/1500）。担任IEEE International Ultrasonics Symposium的分会场主席，受邀加入美国声学学会青年声学工作者进修班，并担任多个国际高水平期刊包括Advanced Materials，Journal of Controlled Release，Theranostics的审稿人。

发表：

期刊

1. Ye DZ, Chukwu C, Yang YH, Hu ZT, Chen H., Adeno-associated virus vector delivery to

the brain: Technology advancements and clinical applications, Advanced Drug Delivery Reviews, 211，115363，2024 Link

2. Ye DZ*, Chen S*, Liu YJ, Weixel C, Hu ZT, and Chen H, Mechanically manipulate glymphatic transportation by ultrasound combined with microbubbles, Proceedings of the National Academy of Sciences 120 (21), e2212933120, 2023 (*co-first author) Link

3. Ye DZ, Yuan JY, Yang YH, Yue YM, Hu ZT, Fadera S, Chen H, Incisionless targeted adeno-associated viral vector delivery to the brain by focused ultrasound-mediated intranasal administration, eBioMedicine, 84: 104277, 2022 Link

4. Ye DZ, Yuan JY, Yue YM, Robin J, Chen H, Focused ultrasound-enhanced delivery of intranasally administered anti-programmed cell death-ligand 1 Antibody to an intracranial murine glioma model, Pharmaceutics, 13(2): 190, 2021 Link

5. Ye DZ, Luan JY, Pang H, Yang YH, Nazeri A., Robin J, Chen H, Characterization of focused ultrasound-mediated intranasal delivery for noninvasive localized drug delivery to the brainstem, Journal of Controlled Release, 328: 276-285, 2020 Link

6. Ye DZ* , Zhang XH*, Yue YM, Tai YC, Robin J, Liu YJ, Chen H, Focused ultrasound-enhanced intranasal delivery of gold nanoclusters to the pons with minimized systemic exposure, Journal of Controlled Release, 286: 145-153, 2018 (*co-first author) Link

7. Ye DZ* , Sultan D*, Luehmann H, Tai YC, Robin J, Liu YJ, Chen H, Focused ultrasound-enabled delivery of radiolabeled nanoclusters to the pons, Journal of Controlled Release, 286: 143-150, 2018 (*co-first author) Link

8. Ye DZ, Bogner R., Li JQ, Fan TH, Dissolution of a colloidal particle in an oscillatory flow, International Journal of Heat and Mass Transfer, 107: 489-499, 2017 Link

9. Ye DZ, Chen H, Focused ultrasound-mediated intranasal brain drug delivery technique (FUSIN), MethodsX, 8: 101266, 2021 Link

10. [Zhang XH*, Ye DZ*], Yang LH, Yue YM, Sultan D, Pacia CP, Pang H, Detering L, Luehmann H, Tai YC, Robin J, Chen H, Liu YJ, Magnetic resonance imaging-guided focused ultrasound-based delivery of radiolabeled copper nanoclusters to diffuse intrinsic pontine glioma, ACS Applied Nano Materials, 3(11): 11129–11134, 2020 (co-first author) Link

11. [Sultan D*, Ye DZ*], Luehmann H, Tai YC, Robin J, Chen H, Liu YJ. Targeted delivery of different charged 64Cu-coujugated nanoclusters across the blood-brain barrier using focused ultrasound, Small, 1703115, 2018 (co-first author) Link

12. Hu ZT, Yang YH, Yang LQ, Gong Y, Chukwu C, Ye DZ, Yue YM, Kravitz A, Chen H*, Airy-beam holographic sonogenetics for advancing neuromodulation precision and flexibility. Proceedings of the National Academy of Sciences, 121 (26) e2402200121，2024 Link

13. Yang YH, Yuan JY, Field RL, Ye DZ, Hu ZT, Xu K, Gong Y, Yue YM, Kravitz A, Bruchas MR, Cui JM, Brestoff JR, and Chen H, Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound, Nature Metabolism, 5, 789–803, 2023 Link

14. Hu ZT, Yang YH, Ye DZ, Chen S, Gong Y, Chukwu C, Chen H* , Noninvasive and spatially targeted delivery of therapeutic agents to the mouse brain using a stereotactic-guided miniature focused ultrasound device, STAR Protocols, 4 (1):102132, 2023 Link

15. Pan SL, Ye DZ, Yue YM, Yang LH, Pacia CP, Dahiya S, Limbrick DD, Robin J, Chen H, Strahle JM, Leptomeningeal disease and tumor dissemination along CSF pathways in a murine DIPG model: implications for study of the tumor-CSF-ependymal microenvironment, Neuro-oncology Advances, 4(1): vdac059, 2022 Link

16. Gong Y, Ye DZ, Chien CY, Yue YM, and Chen H, Focused ultrasound for efficient and homogenous delivery of immune checkpoint inhibitor to brainstem. IEEE Transactions on Biomedical Engineering, 3221887.1, 2022 Link

17. Yuan JY, Ye DZ, Chen S, Chen H, Therapeutic ultrasound-enhanced immune checkpoint inhibitor therapy, Frontiers in Physics, 9: 102, 2021 Link

18. LeMoyne HG, Ye DZ, Carpenter J, Prior J, Marsala L, Mixdorf M, Rubin J, Chen H, Achilefu S, Intracranial glioma xenograft model rapidly reestablishes BBB integrity for longitudinal imaging of tumor progression using fluorescence molecular tomography, Journal of Biomedical Optics, 25(2): 026004, 2020 Link

19. Xu SS, Ye DZ, Wan L, Shentu YJ, Yue YM, Wan MX, Chen H, Correlation between brain tissue damage and cavitation doses quantified using passive cavitation imaging, Ultrasound in Medicine & Biology, 45(10): 2758-2766, 2019 Link

20. Yang YH, Pacia CP, Ye DZ, Yue YM, Chien CY, Chen H, The magnetic field reduces focused ultrasound-induced microbubble cavitation activity and blood-brain barrier opening outcomes, Radiology, 3: 204441, 2021 Link

21. Yang YH, Pacia CP, Ye DZ, Zhu L, Baek H, Yue YM, Yuan JY, Miller MJ, Cui J, Culver JP, Bruchas MR, Chen H, Sonogenetics for noninvasive and cellular-level neuromodulation in rodent brain, Brain Stimulation, 14(4): 790-800, 2021 Link

22. Yang YH, Zhang XH, Ye DZ, Liu YJ, Chen H, Cavitation dose painting for focused ultrasound-induced blood-brain barrier disruption, Scientific Reports, 9(1):2840, 2019 Link

23. Zhu LF, Cheng G, Ye DZ, Nazeri A., Yue YM, Liu WJ, Wang XW, Gavin P., Allegra A., Eric C., Chen H, Focused ultrasound-enabled brain tumor liquid biopsy, Scientific Reports, 8(1):6553, 2018 Link

24. Chen S, Nazeri A, Baek H, Ye DZ, Yang YH, Yuan JY, Chen H, A review of bioeffects induced by focused ultrasound combined with microbubbles on the neurovascular unit, Journal of cerebral blood flow and metabolism, 42(1):3-26, 2021 Link

25. Hu ZT, Xu L, Chien CY, Yang YH, Gong Y, Ye DZ, Pacia CP, Chen H, Three-dimensional transcranial microbubble cavitation localization by four sensors, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 68(11):3336-3346, 2021 Link

26. Song H., He CR, Basdeo C, Li JQ, Ye DZ, Kalonia D, Li SY, Fan TH, Evaporation of binary mixtures and precision measurement by crystal resonator, International Journal of Heat and Mass Transfer, 100: 800-809, 2016 Link

会议

1. Ye DZ, Zhang XH, Yang YH, Yue YM, Tai YC, Robin J, Liu YJ, Chen H., Comparison of focused ultrasound-mediated intranasal delivery and focused ultrasound-induced blood-brain barrier disruption in the delivery of gold nanoclusters to the brainstem, IEEE International Ultrasonics Symposium (IUS), 1-9, 2018 Link

书籍

1. Ye DZ, Chen H. Focused ultrasound-mediated intranasal brain drug delivery technique

(FUSIN), Biomedical Engineering Technologies: Volume 1 (Methods in Molecular

Biology, 2393) 1st ed. Link

会议报告

1. Ye DZ, Yuan JY, Yang YH, Yue YM, Hu ZT, Fadera S, Chen H, Focused ultrasound-mediated intranasal delivery for AAV delivery to targeted brain regions with minimal systemic exposure, 8th International Symposium on Focused Ultrasound, Bethesda. MD, 2022

2. Ye DZ, Chen S, Liu YJ, Weixel C, Hu ZT, Chen H, Ultrasound with microbubbles accelerates glymphatic transportation, 8th International Symposium on Focused Ultrasound, Bethesda. MD, 2022

3. Ye DZ, Chen S, Liu YJ, Weixel C, Hu ZT, Chen H, Ultrasound with microbubbles accelerates glymphatic transportation, IEEE International Ultrasonics Symposium, Venice, Italy, 2022

4. Ye DZ, Chen S, Liu YJ, Weixel C, Hu ZT, Chen H, Focused ultrasound mediated intranasal delivery by enhancing the glymphatic transportation, International Symposium on Therapeutic Ultrasound, Toronto, CA, 2022

5. Ye DZ, Yuan JY, Yue YM, Robin J, Chen H, Focused Ultrasound-Enhanced Delivery of Intranasally Administered Anti-Programmed Cell Death-Ligand 1 Antibody to an Intracranial Murine Glioma Model, 181st Meeting of the Acoustical Society of America, Seattle, Washington, 2021

6. Ye DZ, Zhang XH, Yang LH, Yue YM, Sultan D, Pacia CP, Pang H, Detering L, Luehmann H, Tai YC, Robin J, Chen H, Liu YJ, Focused ultrasound-enhanced delivery of radiolabeled agents to diffuse intrinsic pontine glioma, SNO Pediatric Neuro-Oncology Research Conference, virtual, 2021

7. Ye DZ, Yuan JY, Yue YM, Robin J, Chen H, FUS-mediated intranasally administered delivery of immune checkpoint inhibitors to brain tumors, International Ultrasonics Symposium, 2021

8. Ye DZ, Yuan JY, Yue YM, Robin J, Chen H, FUS-mediate intranasally administered delivery of immune checkpoint inhibitors to brain tumors, Controlled Release Society 2021 virtual annual meeting, virtual, 2021

9. Ye DZ, Zhang XH, Yue YM, Tai YC, Robin J, Liu YJ, Chen H., Comparison of focused ultrasound-mediated intranasal brain drug delivery and focused ultrasound-induced blood-brain barrier disruption in the delivery of gold nanoclusters to the brainstem, IEEE International Ultrasonics Symposium, Kobe, Japan, 2018

10. Ye DZ, Zhu LF, Yue YM, Chen H. Intranasal administration of temozolomide combined with focused ultrasound to enhance the survival of mice with glioma (a pilot study), 175th Meeting of the Acoustical Society of America, Minneapolis, MI, 2018 [Best Paper Award]

11. Ye DZ, Zhang XH, Yue YM, Tai YC, Robin J, Liu YJ, Chen H., Focused ultrasound-enhanced intranasal delivery of gold nanoclusters to the pons with minimized systemic exposure, International Symposium on Therapeutic Ultrasound, Nashville, TN, 2017 [Oral Presentation and Poster Competition Finalist]

12. Ye DZ, Federico C, Kapoor V., Thotala D., Hallahan D.E., Azab K., Chen H, Integration of focused ultrasound with nanomedicine for brain drug delivery, 173rd Meeting of the Acoustical Society of America, Boston, MA, 2017 [Oral Presentation and Poster Competition Finalist]

13. Ye DZ, Raliya R, Biswas P, Chen H. Focused ultrasound-enhanced intranasal brain delivery of gold nanoparticles. IEEE International Ultrasonics Symposium, Tours, France, 2016

14. Ye DZ, Bogner R., Li JQ, Fan TH, Flow dynamics on the reconstitution of lyophilized products, American Physical Society, Denver, CO, 2014

会议海报

15. Ye DZ, Chen S, Liu YJ, Weixel C, Hu ZT, Chen H, Focused ultrasound (FUS) with microbubbles accelerates glymphatic transportation, The 15th International Conference on Ultrasound Engineering for Biomedical Applications, Torrance. CA, USA, 2023

16. Ye DZ, Yuan JY, Yang YH, Yue YM, Hu ZT, Fadera S, Chen H, Focused ultrasound-mediated intranasal delivery for AAV delivery to targeted brain regions with minimal systemic exposure, American Society of Gene + Cell Therapy (ASGCT) Annual Meeting, Los Angeles. CA, USA, 2023 [Outstanding Poster Award]

17. Ye DZ, Chen S, Liu YJ, Weixel C, Hu ZT, Chen H, Ultrasound with microbubbles accelerates glymphatic transportation, Brain Immunology and Glia Symposium, Saint Louis, USA, 2022 [Nature Neuron Award]

18. Ye DZ, Yuan JY, Yang YH, Yue YM, Hu ZT, Fadera S, Chen H, Focused ultrasound-mediated intranasal delivery for AAV delivery to targeted brain regions with minimal systemic exposure, IEEE International Ultrasonics Symposium, Venice, Italy, 2022

19. Ye DZ, Zhang XH, Yang LH, Yue YM, Sultan D, Pacia CP, Pang H, Detering L, Luehmann H, Tai YC, Robin J, Chen H, Liu YJ, Magnetic resonance imaging-guided focused ultrasound-based delivery of radiolabeled copper nanoclusters to diffuse intrinsic pontine glioma, IEEE International Ultrasonics Symposium, virtual, 2020

20. Ye DZ, Luan JY, Pang H, Yang Y, Chen H, Characterization of focused ultrasound-mediated intranasal delivery for noninvasive localized drug delivery to the brainstem, IEEE International Ultrasonics Symposium, virtual, 2020

21. Ye DZ, Sultan D, Luehmann H, Tai YC, Robin J, Liu YJ, Chen H., Focused ultrasound-enabled delivery of radiolabeled nanoclusters to the pons with concurrent PET imaging, International Symposium on Therapeutic Ultrasound, Nanjing, China, 2017